History of Urine Pregnancy Test

Patsama Vichinsartvichai

MD., MClinEmbryol., 
EFOG-EBCOG., EFRM-ESHRE/EBCOG. 

The urine pregnancy test (UPT)

 is a well-known tool that many individuals have used to determine pregnancy. These tests work by detecting the presence of the hormone human chorionic gonadotropin (hCG) in urine. When a woman becomes pregnant, her body starts producing this hormone.

Historically, the methods for determining pregnancy were varied and often not as direct or reliable as today's urine tests. Here's a brief overview:

Ancient Egyptian Method: 

One of the earliest documented pregnancy tests comes from ancient Egypt. Women would urinate on wheat and barley seeds. If the seeds germinated, the woman was believed to be pregnant. Interestingly, this method showed some validity when tested in the 20th century!

Middle Ages: 

During the Middle Ages, “piss prophets” claimed they could determine pregnancy by the color and characteristics of a woman’s urine. Sometimes, these urine samples were also mixed with wine or other substances to observe reactions.

Rabbit Test (1930s): 

This was a more scientific approach where women's urine was injected into young female rabbits. If the rabbit ovulated, which could be determined only by dissecting the animal, then the test was positive. This was because the hCG hormone, which indicates pregnancy, would induce ovulation in the rabbit.

Modern UPTs: 

The first modern pregnancy tests were developed in the 1960s, and they became widely available in the 1970s. These relied on the principle of detecting hCG in a woman's urine using antibodies. Today's tests are far more advanced, offering results within minutes and boasting over 99% accuracy when used correctly.


These tests have come a long way from ancient grains to modern biochemistry. It is a reflection of human innovation and the constant drive to understand the mysteries of the body.


Love,


Dr. Pat

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